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• MY Thesis Work Involved Studying the Epstein Barr Virus (Ebv) Oncoprotein, Latent Membrane Protein-1 (Lmp-1). Lmp-1 is A Six Membrane-Spanning Transmembrane Protein That Functions as A Constitutively Active Cd40 Analog. Lmp-1 Interacts with Multiple Proteins Including Tnfr Associated Factors (Trafs), Tradd, Pi3-K, and Jak3 to Activate Nf-κB, Jnk/Ap-1, Akt, and Stat Pathways. These Signaling Events Result in Proliferation, Survival, and Transformation of the Host Cell. Along with Studying These… Show More MY Thesis Work Involved Studying the Epstein Barr Virus (Ebv) Oncoprotein, Latent Membrane Protein-1 (Lmp-1). Lmp-1 is A Six Membrane-Spanning Transmembrane Protein That Functions as A Constitutively Active Cd40 Analog. Lmp-1 Interacts with Multiple Proteins Including Tnfr Associated Factors (Trafs), Tradd, Pi3-K, and Jak3 to Activate Nf-κB, Jnk/Ap-1, Akt, and Stat Pathways. These Signaling Events Result in Proliferation, Survival, and Transformation of the Host Cell. Along with Studying These Signaling Pathways, i Discovered That Lmp-1 Also Interacts with the Janus Kinase Tyk2. Tyk2 is an Important Kinase Within the Type i Interferon (Ifn) Signaling Pathway. MY Work Involved Characterizing the Effects of Lmp-1 on Tyk2 Kinase Activity and on Type i Interferon Signaling. Show Less