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• • Used Mouse Models to Study Stem Cell Function in Skin Development, Regeneration, and Wound Repair. • Discovered Transcription Factor Nfib Plays A Critical Role in Mediating the Crosstalk Between Epithelial- and Melanocyte-Stem Cells to Sustain Hair Follicle Regeneration and Pigmentation. • Established Tissue-Specific Conditional Knockout Mouse Lines and Used Immunostaining and Histology to Characterize Mouse Phenotypes. • Conducted in Vivo Signaling Perturbation by Subcutaneous… Show More • Used Mouse Models to Study Stem Cell Function in Skin Development, Regeneration, and Wound Repair. • Discovered Transcription Factor Nfib Plays A Critical Role in Mediating the Crosstalk Between Epithelial- and Melanocyte-Stem Cells to Sustain Hair Follicle Regeneration and Pigmentation. • Established Tissue-Specific Conditional Knockout Mouse Lines and Used Immunostaining and Histology to Characterize Mouse Phenotypes. • Conducted in Vivo Signaling Perturbation by Subcutaneous Injection with Small-Molecule Inhibitors and Antagonizing Antibodies. • Performed in Vivo Chromatin-Immunoprecipitation Sequencing (Chip-Seq) and Transcriptome (Rna-Seq) Analyses Using Facs-Sorted Epithelial Cells for Mechanistic Studies. • Developed and Executed Cell-Based Assays, Reporter Assays, in Vitro and in Vitro Shrna Knockdown and Gene Overexpression for Dissecting Gene Function. Show Less
• • Investigated the Molecular Basis of Autophagy Using Yeast Genetics • Characterized the Function of Cargo Receptor Atg19 and Showed Atg19 Relied on the Interactions with Both Atg11 and Atg8 to Link Cargos to Vesicular Trafficking Machinery During Autophagy • Identified the Direct Interaction Between Atg11 and Atg9 for Autophagosome Formation and Mapped Their Binding Domains